Clinical Trial Complexity Index →

{
  "product_id": "ADW-377",
  "entity": "Global-ClinicalTrials",
  "score": 50,
  "trend": "stable",
  "confidence": 0.82,
  "top_drivers": [
    {
      "factor": "late_phase_share_pct",
      "contribution": 10.48
    },
    {
      "factor": "large_enrollment_share_pct",
      "contribution": 9.89
    },
    {
      "factor": "industry_sponsored_share_pct",
      "contribution": 17.81
    },
    {
      "factor": "randomization_rate_pct",
      "contribution": 60.09
    },
    {
      "factor": "high_blinding_rate_pct",
      "contribution": 22.35
    },
    {
      "factor": "total_recruiting_active_trials",
      "contribution": 87372
    }
  ],
  "recommended_use": "Track the structural complexity of the active global clinical-trial landscape. Rising scores indicate the R&D environment is shifting toward more resource-intensive designs (later-phase, large randomized blinded studies). Useful for CRO capacity planning, biotech/pharma investment screening, and regulatory burden forecasting. Descriptive only — not a drug-efficacy signal.",
  "methodology_version": "ADW-377-live-1.0",
  "freshness": "2026-06-27T04:00:21.192Z",
  "coverage": "All actively recruiting or active-not-recruiting clinical studies registered on ClinicalTrials.gov (FDAAA 2007 mandatory registry). Global scope including US, EU, and international sites. Covers interventional and observational designs.",
  "source_lineage": [
    "clinicaltrials.gov/api/v2/studies — filter.overallStatus=RECRUITING,ACTIVE_NOT_RECRUITING",
    "clinicaltrials.gov/api/v2/studies — filter.advanced=AREA[Phase]PHASE3",
    "clinicaltrials.gov/api/v2/studies — filter.advanced=AREA[Phase]PHASE4",
    "clinicaltrials.gov/api/v2/studies — filter.advanced=AREA[EnrollmentCount]RANGE[1000,MAX]",
    "clinicaltrials.gov/api/v2/studies — filter.advanced=AREA[LeadSponsorClass]INDUSTRY",
    "clinicaltrials.gov/api/v2/studies — filter.advanced=AREA[DesignAllocation]RANDOMIZED",
    "clinicaltrials.gov/api/v2/studies — filter.advanced=AREA[DesignMasking]TRIPLE|QUADRUPLE"
  ],
  "allowed_use": "informational",
  "validation_status": "descriptive",
  "total_recruiting_active_trials": 87372,
  "phase3_count": 6267,
  "phase4_count": 2886,
  "large_enrollment_count": 8637,
  "industry_sponsored_count": 15565,
  "interventional_count": 64674,
  "randomized_count": 38860,
  "triple_blind_count": 3585,
  "quadruple_blind_count": 5099,
  "dimension_shares": {
    "late_phase": 0.1048,
    "large_enrollment": 0.0989,
    "industry_sponsored": 0.1781,
    "randomized": 0.6009,
    "high_blinding": 0.2235
  },
  "composite_raw": 0.20425,
  "baseline_composite": 0.20428,
  "next_fresh_at": "2026-07-27T04:00:21.192Z",
  "failed_fetches": 0,
  "data_notes": [
    "Enrollment counts are registrant-estimated; some studies over-report anticipated size.",
    "Phase is self-reported; occasional mislabeling possible for novel platform trials.",
    "ACTIVE_NOT_RECRUITING includes studies near wind-down (may slightly inflate complexity).",
    "Score baseline 50 calibrated to 2026-06-25 live CT.gov snapshot (87,290 active trials)."
  ]
}